Selected Publications

  1. Humblin E et al. Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1+ PD-1+ CD8 T cells. Science Immunology (2023) https://doi.org/10.1126/sciimmunol.adg0878.     Link for free acess 

  2. Filipescu, D., Carcamo, S., Agarwal, A. et al. MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping. Nat Cell Biol (2023). https://doi.org/10.1038/s41556-023-01208-7

  3. Park, M.D., Reyes-Torres, I., LeBerichel, J. et al. TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nat Immunol 24, 792–801 (2023). https://doi.org/10.1038/s41590-023-01475-4

  4. Magen A*, Hamon P* et.al. Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma. Nat Med (2023). httpPark, M.D., Reyes-Torres, I., LeBerichel, J. et al. TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nat Immunol 24, 792–801 (2023). https://doi.org/10.1038/s41590-023-01475-4s://doi.org/10.1038/s41591-023-02345-0 (Corresponding authors: Marron TU*, Thurston G*, Kamphorst AO* and Merad M*)

  5. V van der Heide, E Humblin, A Vaidya, AO Kamphorst, Advancing beyond the twists and turns of T cell exhaustion in cancer. Science Translational Medicine, 2022 Nov 9;14(670):eabo4997. Pubmed PMID: 36350991; PMCID: PMC10000016

  6. Jansen CS, Prokhnevska N, Master VA, et al. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells. Nature. 2019;576(7787):465-70. PubMed PMID: 31827286; PMCID: PMC7108171

  7. Ruiz de Galarreta M, Bresnahan E, Molina-Sanchez P, et al. beta-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma. Cancer Discov. 2019;9(8):1124-41. PubMed PMID: 31186238; PMCID: PMC6677618.

  8. Humblin E, Kamphorst AO. CXCR3-CXCL9: It's All in the Tumor. Immunity. 2019;50(6):1347-9. PubMed PMID: 31216458.

  9. Wieland A*, Kamphorst AO*, Adsay NV, et al. T cell receptor sequencing of activated CD8 T cells in the blood identifies tumor-infiltrating clones that expand after PD-1 therapy and radiation in a melanoma patient. Cancer Immunol Immunother. 2018. PubMed PMID: 30167863; PMCID: PMC6196100.

  10. Hashimoto M*, Kamphorst AO*, Im SJ, et al. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions. Annu Rev Med. 2018;69:301-18. PubMed PMID: 29414259.

  11. Kamphorst AO, Wieland A, Nasti T, et al. Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent. Science. 2017. PubMed PMID: 28280249; PMCID: PMC5595217.

     
  12. Kamphorst AO, Pillai RN, Yang S, et al. Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients. Proc Natl Acad Sci U S A. 2017;114(19):4993-8. PubMed PMID: 28446615; PMCID: PMC5441721.

     
  13. Kamphorst AO, Araki K, Ahmed R. Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine. 2015;33 Suppl 2:B21-8. PubMed PMID: 26022562; PMCID: PMC4449453.

  14. Penaloza-MacMaster P*, Kamphorst AO*, Wieland A, et al. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med. 2014;211(9):1905-18. PubMed PMID: 25113973; PMCID: PMC4144726.

  15. Kamphorst AO, Ahmed R. Manipulating the PD-1 pathway to improve immunity. Curr Opin Immunol. 2013;25(3):381-8. PubMed PMID: 23582509; PMCID: PMC5946314.

  16. Kamphorst AO, Ahmed R. CD4 T-cell immunotherapy for chronic viral infections and cancer. Immunotherapy. 2013;5(9):975-87. PubMed PMID: 23998732; PMCID: PMC3864579.

  17. Aubert RD, Kamphorst AO, Sarkar S, et al. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A. 2011;108(52):21182-7. PubMed PMID: 22160724; PMCID: PMC3248546.

     * Equal Contribution 

    Complete List of Published Work: https://www.ncbi.nlm.nih.gov/pubmed/?term=kamphorst+ao