https://kamphorstlab.org/home daily 1.0 2025-08-07 https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/7d308502-e579-4843-941e-fbb6a28285e9/Escape_Room.jpeg Home https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/e8e7ccde-8adf-460f-bf41-1b703e450b69/escape.jpeg Home https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/ca37b122-b54b-4d53-a5b7-1c2eb06fd8ee/IMG_0147.jpeg Home https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/55594318-d675-4d78-8aae-e7890b5bcf20/%23immune2cancer.jpeg Home #Immune2cancer https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/26e2c1ad-4777-4e6c-8574-9eb80b65d00a/group+4A1A6766.jpeg Home https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/8362326f-0c9c-4f34-a49c-26a6336aa008/Group2.jpg Home https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/94a79fb5-2059-4590-881d-1666b8e2ce30/F5EC9097-3BC6-419F-A36B-1A4B70A81DBB_1_105_c.jpeg Home Ashley's Master Thesis Defence Celebrations https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/14030cf4-eb98-4535-af7f-ce9e338fba16/IMG_5011.jpg Home https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/96491629-d152-462d-b22f-386f259977a2/group.jpeg Home Lab Outing https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/565a99d8-ddf3-47f1-97e3-8d43b08301da/lab.png Home Educate your immune system https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/40cbc1e7-286a-464a-b8bd-024408570932/labpicnic.jpg Home https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1626055692434-ACVODF35DZJADBT558AM/group+4A1A6719.jpeg https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1622342097841-QGWJYHHMSHSQF1FVIYDC/IMG_0312.jpeg Home - Contact Us Interested in working on T cell immunology? https://kamphorstlab.org/publications daily 0.75 2026-03-19 https://kamphorstlab.org/members daily 0.75 2021-06-11 https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1622340080464-VSMDLX9EA202VVXS0NQD/0000072500067510172801.png Members - Alice Kamphorst Alice O. Kamphorst, Ph.D. is an Assistant Professor of Oncological Sciences at the Precision Immunology Institute. She is also a member of the Cancer Immunology Research Program at the Tisch Cancer Institute. She received her Ph.D. from The Rockefeller University, studying antigen presentation and dendritic cell biology with the mentorship of Michel Nussenzweig. In her post-doctoral studies, Alice worked on T cells and PD-1 immunotherapy with Rafi Ahmed at Emory University. https://kamphorstlab.org/collaboration daily 0.75 2021-07-30 https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627656922597-ZAUQCB9149NZH90NVEVJ/miriammerad-e1468946503575.png Collaborations https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627657084830-0MPG17GBYDLZ8OFIZG05/Brian_Brown_square.jpeg Collaborations https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627657128430-71HSFCN8TW9APAU8K9XB/lujambio.jpeg Collaborations https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627657178849-WUFWZTQBAG0Z26M9N3QH/Dirk-Homann.jpeg Collaborations https://kamphorstlab.org/science daily 0.75 2023-09-21 https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627659601927-9IU94UBPSMSEXXT1JSNG/miriammerad-e1468946503575.png Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627659729108-ZM5ECXMRFQX6OP606O1Z/Brian_Brown_square.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627659789185-XX4Q2K1EIPWA6LSYINWL/lujambio.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627659859736-ID24BSISEQDVABJKRHBV/ba221d45892dacd01b909ede57be05c8192e173f.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1628278700900-L60VXX7GK6Y3016XXSNO/Jerry-Chipuk.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1628278745930-O0VI0A910RR2GUB6LWYH/Emily+B.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1628278855423-PGCA9UG2LW3THP6Z3MEE/Thomas.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1628637234873-LIXH69UBYXNXMIHZK6IE/sergio.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1628637601066-13ZQVL1ZSPFU1N8TCUMY/Victora.jpg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629807570426-Z0RJXM2YS99RDY3P5EBQ/scott+.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629826584929-S664BQYVLJIFW3T6Y7NV/ahmed_r.gif Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/6f383008-cd2b-474d-82a1-f4f8d80246a3/Rosenberg_Brad.jpeg Science https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629816992311-YBC0DDG3CAQCDNB2LP4P/antigen+presentation.jpeg Science - T cell costimulation Recent findings identified that PD-1+ CD8 T cells recognizing tumor or chronic pathogens have a division of labor: T cell factor TCF-1+ PD-1+ CD8 T cells function as progenitor cells (Tpex) whereas TCF-1neg PD-1+ CD8 T cells can either be terminally differentiated/exhausted (Tex) or retain some effector-like function (Teffex). TCF-1+ Tpex cells have high expression CD28, and we have shown that during PD-1 targeted therapies CD28 costimulation is required for the reinvigoration of CD8 T cell responses. We now investigate how CD28 and other costimulatory molecules impact function and fate decisions in Tpex and thus modulate PD-1+ CD8 T cell responses. https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629809869490-YAMCJG71ILQZ8M7WQMI9/Victoralab.jpg Science - T cell interactions In addition to a unique set of costimulatory molecules, TCF-1+ Tpex cells also express a distinct set of chemokine/cytokine receptors. In collaboration with the Victora lab, we use LIPSTIC (Labeling of Immune Partnerships by SorTagging Intercellular Contacts) to study how cell-cell interactions in vivo impact the differentiation of CD8 T cells. https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/2279d1d6-39bb-43b8-bc97-f0a8cb565db8/CD4help.jpg Science - CD4 T cell Help Even though the role of CD4 T cells in helping immune responses has been extensively studied, a mechanistic understanding of how CD4 T cells impact CD8 T cell responses in tissues and cancer is still lacking. During persistent antigen stimulation, CD4-help enhances the differentiation of effector-like PD-1+ CD8 T cells (Teffex). We are now addressing at the molecular and cellular level - the effects of CD4-help for anti-tumor immunity. https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/e4b89586-4cad-4643-ba1a-af659a650ff3/liver.jpg Science - T cell responses in Hepatocellular Carcinoma In collaboration with the Merad lab, Thomas Marron, and many others, using CyTOF, scRNA/CITE-seq, and multiplex tissue staining by MICSSS, we analyze resected liver tissue from HCC to study T cell differentiation in cancer patients. We then perform mechanistic studies in a novel mouse model of HCC (developed by the Lujambio lab) to uncover fundamental aspects of T cell dysfunction and reinvigoration. https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629809781153-U4CT2UH8KYUXRZNK0FHY/crispr.jpeg Science - T cell Differentiation in vivo In collaboration with the Brown lab, we use CRISPR-based genetic tools to study T cell differentiation in vivo. We are particularly interested in deciphering gene programs that promote the differentiation of chronically stimulated CD8 T cells into effective functional effector-like cells (Teffex). https://kamphorstlab.org/contact daily 0.75 2023-09-21 https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/a5011e83-e94b-4c35-9811-08e321a97bbd/PRIISM_logo.jpeg https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627660605383-9YGMF7OAIKJ0M6JDCQ4V/NIH.png https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1627660926453-BKXLOAB90KK2ELTQBKZ4/images.png https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/51eee9b0-22f4-4042-801d-a8153cde8465/MERK.png https://kamphorstlab.org/our-team daily 0.75 2023-02-23 https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1657664864773-1LSK6RXYBQHDCS0U730F/Ashlet.jpg https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1623463184336-PGBEYTENUYICMNVIGI72/203.jpeg Our Team - Verena Van Der Heide Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1623463170006-NH0HJWC2JDYS98G4HG1Z/ashley.jpeg Our Team - Ashley Lu Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1623462845465-R69FEDV2772LTNXEXVUZ/citations.jpeg Our Team - Abishek Vaidya Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://kamphorstlab.org/team daily 0.75 2026-03-19 https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629846783870-E4SWPX9YD8GKOONYLTV0/Abishek.JPG Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629907073996-XELY1YN7UB6KPHT11GYA/Ver.JPG Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1657664864773-1LSK6RXYBQHDCS0U730F/Ashlet.jpg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1637704930045-UD6AJKP93ESC5KVBWDKI/Simon.jpeg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/897a7c5d-13a6-4668-a7ca-677b19513ce7/Nataliya.jpeg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/4b2971bd-08e2-4a9f-a3ab-3bdc68cb9696/Sarah_Use.jpg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/15e15f72-28b5-4ab5-bf9f-ff5a6b6cf05a/Isabel_use.jpg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/bed7c2ea-85c4-42c6-9b87-368fef68c825/group.jpg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/c4c238c5-60d3-4e5c-be23-c7abe594ff0b/group.jpg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/58942edb-b258-4ae2-9c8d-45b0c65722e1/Suhaana.jpg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/a85b1525-03ff-43d3-962e-454accca591c/Chi.jpg Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629846286068-N0EW1MFIAGNO7E2UMM99/4A1A6976.JPG Our Team https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1625870970821-GLTAXRETC63KBKLQELWM/AK+headshot.jpeg https://kamphorstlab.org/our-teamnew-style daily 0.75 2022-08-25 https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629846306690-JEIJ8MKUMHWS3IQ9B3BL/4A1A6976.JPG Our Team-new style https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629907073996-XELY1YN7UB6KPHT11GYA/Ver.JPG Our Team-new style https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629846783870-E4SWPX9YD8GKOONYLTV0/Abishek.JPG Our Team-new style https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1637704930045-UD6AJKP93ESC5KVBWDKI/Simon.jpeg Our Team-new style https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1657664864773-1LSK6RXYBQHDCS0U730F/Ashlet.jpg Our Team-new style https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1657665395376-YXKBNMEALVV5RHNKYN3B/ICMMS.png Our Team-new style https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1657665584113-DASOQM3HOZ92XR1FP9X0/ICMMS.png Our Team-new style https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1625870970821-GLTAXRETC63KBKLQELWM/AK+headshot.jpeg https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629846306690-JEIJ8MKUMHWS3IQ9B3BL/4A1A6976.JPG https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629907073996-XELY1YN7UB6KPHT11GYA/Ver.JPG https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1629846783870-E4SWPX9YD8GKOONYLTV0/Abishek.JPG https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1637704930045-UD6AJKP93ESC5KVBWDKI/Simon.jpeg https://images.squarespace-cdn.com/content/v1/60b2e5393fc94d2e778ed34b/1657665395376-YXKBNMEALVV5RHNKYN3B/ICMMS.png